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Substrate specificity of protein kinase C. A unique cytogenetic-clinicopathological association. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Leukemia and the disruption of normal hematopoiesis. National Center for Biotechnology Information , U. Abstract A t 4;16 q26;p RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

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Three-dimensional structure of membrane and surface proteins. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia.

The open reading frame of BCM normal cDNA predicted a amino acid protein with a single transmembrane domain which had no homology with any protein sequence stored in data banks. The t 14;18 chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Two distinct loci on the short arm of chromosome 16 are involved 586 myeloid leukemia. Point mutations define a sequence flanking the AUG initiator codon bc, modulates translation by eukaryotic ribosomes.

Nucleotide sequence of a t 14;18 chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.


A new specific chromosomal rearrangement, t 8;16 p11;p13in acute monocytic leukaemia. For this reason, the novel gene was termed BCM for B cell maturation. Chromosome abnormalities in poorly differentiated lymphocytic lymphoma.

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A t 4;16 q26;p Human proto-oncogene c-mos maps to 8q Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. This article has been cited by other articles in PMC.

Gene for T-cell growth factor: Please review our privacy 57786. Open in a separate window. Human interleukin 2 gene is located on chromosome 4.

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TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Interleukin 2 mRNA induction in human lymphocytes: Translocations, master genes, and differences 5876 the origins of acute and chronic leukemias. Images in this article Image on p. Acute myelomonocytic leukemia with abnormal eosinophils and inv 16 or bcmm 16;16 has a favorable prognosis.


A simple method for displaying the hydropathic character of a protein. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Substrate specificity of protein kinase C. National Center for Biotechnology InformationU.

Author information Copyright and License information Disclaimer. Leukemia and the disruption of normal hematopoiesis.

N Engl J Med. A new method for predicting signal sequence cleavage sites. Three clones were isolated, which consisted, from 5′ to 3′, of the three first exons of the interleukin 2 gene followed by a 16p13 in-frame bck encoding amino acids.

Chromosomal translocation t 1;19 results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.